The series celebrates the 25th anniversary of its original Super Dimension Fortress Macross TV series (1982~1983), and is chronologically subsequent to Macross 7 (1994~1996). This third TV series introduces Earth's latest main variable fighter, the VF-25 Messiah and a new Warship/starship called the Macross Quarter. The show retains the signature space opera theme consistent with all series set in the Macross Universe (which intertwine musical numbers with fast-paced variable fighter combat). New episodes are aired weekly on the TBS network Fridays at 25:55. The 24+ hour clock is a common Japanese TV broadcast notation, in this case indicating 01:55am Saturday. Two separate manga adaptations have been running in Sho-nen Ace and Comp Ace, since February 2008 and April 2008 respectively.

The series features the 25th New Macross-class Colonial Fleet, dubbed the Macross Frontier, en route to the galactic center. This heavily-populated interstellar fleet (consisting of numerous civilian vessels and their military escorts) contains a makeup of both human occupants and their Zentradi allies. As such, many of the Macross Frontier's companion vessels appear to merge more metallic Human designs with organic Zentradi aesthetics. On the Macross timeline, the story is set in the year 2059, 47 years after the original Super Dimension Fortress Macross, 19 years after Macross Plus and 14 years after the story of Macross 7. Macross Frontier plot explores combination of action/political intrigue/space drama more than previous Macross series have in the past.

As the series begin, during a mission to an unexplored asteroid belt a reconnaissance New U.N. Spacy (N.U.N.S.) VF-171 is destroyed by extremely powerful and fast insectoid biomechanical alien mecha known as the "Vajra", which immediately begin their attack on the rest of the fleet. Not being able to stop the new enemy threat, the N.U.N.S. Colonial Defense Forces authorize the deployment of a Civilian Military Provider organization called S.M.S. (Special Military Services) which utilizes the new VF-25 Messiah variable fighter to destroy the alien menace.

(From Wikipedia)